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An association between gastroesophageal reflux disease (GERD) and asthma is acknowledged widely, but the effect of GERD therapy on asthma control has been inconsistent in previous studies. Some research has suggested a particular association between GERD and nocturnal asthma symptoms.
This industry-sponsored trial included 3 subgroups of adults with stable asthma: One subgroup had nocturnal asthma symptoms and no GERD, one had GERD and no nocturnal asthma symptoms, and one had both GERD and nocturnal asthma symptoms. All 700 patients were randomized to receive either esomeprazole (Nexium; 40 mg) or placebo twice daily. Nearly all patients used inhaled corticosteroids.
The primary outcome was change in mean morning peak expiratory flow (PEF). …