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Moderate alcohol consumption is associated with lower risk for coronary heart disease (CHD), but which is more important: the amount of alcohol consumed or the frequency of intake? And does the answer differ in men versus women? To address these questions, investigators conducted a population-based, cohort study in Denmark among 28,448 women and 25,052 men (age range, 50–65) who were free of CHD at study entry. Subjects completed baseline questionnaires about their average alcohol intake during the past year, and CHD events were tracked using two national registries.
During a median follow-up of 5.7 years, 749 CHD events occurred in women, and 1283 occurred in men. For women, amount of alcohol consumed was a more important determinant of CHD…