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Through the mechanism of hypochlorhydria, proton-pump inhibitors (PPIs) theoretically can reduce calcium absorption and decrease bone density. These investigators sought to clarify the relation between PPI use and risk for hip fracture by using a U.K. population-based registry of 1.8 million patients aged 50 or older. Roughly 400,000 patients received at least one prescription for a PPI, a histamine 2–receptor antagonist (H2RA), or both. A total of 13,556 patients who suffered a hip fracture after at least 1 year of complete data collection were compared with 135,386 controls matched for age and sex.
After adjustment for medications and health conditions affecting the risk for hip fracture, the risk was 44% higher among patients who had used…