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In 2003, an expert committee recommended that the threshold for defining impaired fasting glucose (IFG) be lowered from 110 mg/dL to 100 mg/dL. The new threshold has been widely adopted, and the range for IFG is now defined as 100–125 mg/dL. This study from an Oregon HMO examined the rate of progression from newly acquired IFG to overt diabetes using the new and old IFG criteria.
Researchers identified 5452 nondiabetic people with at least two fasting plasma glucose (FPG) levels in the 100–125 mg/dL range and a documented FPG less than 100 mg/dL preceding the first elevated level. During an average follow-up of about 6 years, the rate of progression to overt diabetes was 1.3% per year among those whose first abnormal FPG was 100–109 mg/dL. I…