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Proton-pump inhibitors were not beneficial for patients with chronic laryngeal symptoms in two placebo-controlled randomized trials published last year (Journal Watch Sep 28 2006). This new study raises additional questions about the diagnosis of reflux laryngitis.
Swiss researchers videotaped the laryngopharyngeal area in patients who were undergoing upper endoscopy for various indications. Later, the videotapes were examined systematically for erythema, edema, and other laryngopharyngeal abnormalities in 132 patients who had esophageal erosions consistent with gastroesophageal reflux disease (GERD), and in 132 age- and sex-matched controls who had a normal esophagus at endoscopy. Among 10 distinct laryngopharyngeal sites that were examined…