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Reducing sodium intake has been demonstrated to lower blood pressure in people with hypertension and to prevent the onset of hypertension in people at risk for it. However, the effect of reducing sodium intake on cardiovascular disease outcomes and mortality remains somewhat controversial. This long-term follow-up study shows a beneficial effect on key outcomes.
U.S. investigators followed up participants in two randomized trials (TOHP I and II) that were completed in the 1990s. All 3126 participants had high normal blood pressure at baseline and were randomized to a sodium reduction intervention or a control group. Follow-up information was obtained from 2415 participants at 10 to 15 years after the original studies ended. The risk for a ca…