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Many different antibiotic regimens are used for children with appendicitis, including aminoglycoside-based triple therapy (ABT) or monotherapy (e.g., cefoxitin or ceftriaxone). Investigators in Seattle used data from a large administrative database of 32 children’s hospitals in the U.S. to compare the use of ABT and monotherapy among 8545 pediatric patients (age ≤18) with discharge diagnoses of ruptured appendicitis and appendectomy between 1999 and 2004.
The percentage of patients who received ABT declined from 69% in 1999 to 52% in 2004. Compared with ABT therapy, treatment with ceftriaxone was associated with lower risk for 30-day readmission for complications such as peritonitis, abcess, infection, obstruction or adhesion (odds ratio, 0.…