Apolipoprotein Ratio Does Not Improve Prediction of Cardiac Risk

The ratio of apolipoprotein B to apolipoprotein A-I was associated with coronary artery disease but added little to existing measures of risk assessment.

Many new risk factors have been found to be associated with coronary artery disease (CAD), but whether they improve risk prediction over established measures is the key question. U.K. researchers evaluated whether the ratio of apolipoprotein B to apolipoprotein A-I was associated with CAD among 869 adults with CAD and 1511 controls matched for age, sex, and time of enrollment.

The highest quartile of the apolipoprotein ratio was significantly associated with fatal and nonfatal CAD (odds ratio, 1.85) in analyses adjusted for cardiovascular risk factors (sex, diabetes, body mass index, smoking, systolic blood pressure, C-reactive protein levels, and LDL and HDL cholesterol levels). The ratio also was associated with CAD (OR, 1.77) in analyses …

Reviewing Author

Richard Saitz, MD, MPH, FACP, FASAM

Apolipoprotein Ratio Does Not Improve Prediction of Cardiac Risk

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Reviewing Author