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High homocysteine levels are associated with risk for venous thromboembolism (VTE), and vitamin supplements can decrease homocysteine levels. But does supplementation decrease the risk for VTE? In a secondary analysis of a previously published multinational randomized controlled trial (Journal Watch Mar 28 2006) designed to assess the effect of homocysteine-lowering therapy on the risk for arterial disease, investigators studied whether daily folate (2.5 mg) and vitamins B6 (50 mg) and B12 (1 mg) affected the risk for symptomatic deep venous thrombosis or pulmonary embolism. Subjects were 5522 adults (age, ≥55) with arterial vascular disease, diabetes, and at least one other cardiovascular disease risk factor.
During a mean follow-up of 5 ye…