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No tests for diagnosing deep venous thrombosis (DVT) in pregnancy are perfect. Researchers prospectively evaluated the diagnostic accuracy of a red blood cell agglutination d-dimer assay (SimpliRED) in 149 consecutive pregnant women with suspected DVT at five referral centers in Canada. All women underwent single or serial compression ultrasonography and were followed for at least 3 months. DVT was diagnosed in 13 women (12 by ultrasonography; 1 developed pulmonary embolism at 2 months).
One woman had equivocal d-dimer results and was excluded. The d-dimer assay was positive in 67 women. Of the 13 women with DVT, all had positive d-dimer test results (sensitivity, 100%). Therefore, all of the 81 women with negative test results did not have …