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Older patients sometimes develop chronic eczematous eruptions of unknown etiology. In a case-control study from France, researchers looked for associations between these rashes and long-term medication use.
The researchers identified 102 patients (age, >60; half inpatients and half outpatients) with chronic eczematous eruptions. Rashes had been present from 3 to 18 months before study entry, had no identified cause, and had histologic features of eczema. Cases were compared with 204 controls who were matched for age, sex, and inpatient or outpatient status. Calcium channel blockers (CCBs; used by 26% of cases and 12% of controls) were the only drug class significantly associated with eczematous rash. In multivariate analysis adjusting for ot…