Loading...
Pregabalin, an amino acid that is structurally similar to the neurotransmitter γ-aminobutyric acid, has analgesic, anticonvulsant, and anxiolytic properties. Small studies of very short duration suggest that pregabalin is effective for treatment of fibromyalgia.
In a multicenter randomized U.S. study, 748 patients with fibromyalgia received either placebo or pregabalin at daily doses of 300, 450, or 600 mg for 13 weeks. Before study entry, patients were required to discontinue almost all medicines (except acetaminophen) that could affect the outcomes measured. Compared with placebo recipients, patients treated at all dose levels of pregabalin had significant improvements in pain, sleep, and overall impression of symptoms. In general, improve…