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Risk for recurrent venous thrombosis (VT) varies: Patients with single major reversible VT risk factors (e.g., recent surgery) have risk for recurrent VT of 3%, whereas those with unprovoked VT have 10% risk for recurrence. In this multinational prospective study in 600 patients with first episodes of unprovoked VT or pulmonary embolism, researchers attempted to identify factors that predicted low recurrence risk. All patients had received 5 to 7 months of anticoagulation before enrollment.
During a mean follow-up of 18 months, the annualized rate of recurrent VT was higher among men than women (13.7% vs. 8.9%). Men with post-thrombotic symptoms (leg hyperpigmentation, edema, or redness) had 24.0% annual risk for recurrence; no subgroup of m…