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The United Kingdom Prospective Diabetes Study (UKPDS) was the first large trial in which researchers compared two levels of glycemic control in patients with new-onset type 2 diabetes. Ten-year results, published in 1998, indicated significantly fewer microvascular — but not macrovascular — complications in intensively treated patients than in conventionally treated patients (JW Oct 2 1998). Now, the researchers present results from 10 years of post-trial follow-up.
Differences in glycosylated hemoglobin (HbA1c) levels between intensively and conventionally treated patients disappeared within 1 year of the trial’s end. Nevertheless, outcomes continued to favor the intensively treated group: During post-trial follow-up, the significant relati…