Does Antibiotic Prophylaxis Prevent UTI Recurrence in Children?

Antibiotic prophylaxis doesn’t prevent recurrent UTI or new renal scars.

Children with urinary tract infections (UTIs) often receive antibiotic prophylaxis to prevent recurrence. In a multisite randomized controlled trial, investigators in Italy compared recurrence rates associated with antibiotic prophylaxis or no prophylaxis in 338 children (age range, 7 months–7 years) who had first febrile UTIs, with or without nonsevere vesicoureteral reflux (VUR; grades I–III); 309 children had documented pyelonephritis as determined by dimercaptosuccinic acid (DMSA) scans.

No significant differences were found between the prophylaxis and no-prophylaxis groups in the primary outcome (recurrence of febrile UTI during 1 year after randomization; 7.1% and 9.5%, respectively) or in the secondary outcome (development of new rena…

Reviewing Author

Howard Bauchner, MD

Disclosures

Grant / research supportHuman Resources and Services Administration; NIH; NIH-NHLBI; USDA; GlaxoSmithKline

Editorial boardsArchives of Disease in Childhood (Editor-in-Chief)

Howard Bauchner, MD

Disclosures

Grant / research supportHuman Resources and Services Administration; NIH; NIH-NHLBI; USDA; GlaxoSmithKline

Editorial boardsArchives of Disease in Childhood (Editor-in-Chief)

Does Antibiotic Prophylaxis Prevent UTI Recurrence in Children?

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Reviewing Author