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Because many hypertensive patients require multiple drugs to control blood pressure (BP), the relative effectiveness of drug combinations is of interest. In the ACCOMPLISH trial, researchers pitted an angiotensin-converting–enzyme inhibitor plus calcium channel blocker against an ACE inhibitor plus diuretic. The trial was sponsored by a manufacturer of a benazepril–amlodipine combination capsule.
Enrollment criteria included age ≥60 and history of hypertension (nearly all patients were already taking antihypertensive drugs at enrollment). In addition, all patients had at least one of the following high-risk criteria: documented coronary disease, history of stroke, peripheral vascular disease, diabetes, left ventricular hypertrophy, elevated …