Four Approaches to Dyspepsia

All yielded similar 1-year outcomes.

Initial approaches to dyspepsia vary considerably among clinicians. In a U.K. trial involving 762 patients (28% age ≥50) with dyspepsia, investigators compared outcomes of four treatment strategies. Patients with symptoms that suggested malignancy and those with previously diagnosed esophagitis or peptic ulcer were excluded.

Patients were randomized to one of four treatment groups:

Early endoscopy: Patients underwent endoscopy with urease testing for Helicobacter pylori (HP) infection. HP-positive patients with ulcers or erosions received treatment to eradicate HP; all others received proton-pump inhibitors (PPIs) for 1 month.
Test and refer: Patients underwent serologic HP testing. HP-positive patients underwent endoscopy and were treated sim…

Reviewing Author

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose

Four Approaches to Dyspepsia

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Reviewing Author