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High-density lipoprotein (HDL) cholesterol level is associated independently and inversely with coronary heart disease risk. Nevertheless, evidence that treatment-mediated increases in HDL cholesterol levels lower CHD risk is lacking. In this analysis of 108 randomized trials, involving nearly 300,000 patients, investigators assessed whether treatment-mediated changes in HDL cholesterol levels are associated with all-cause death, CHD-related death, and adverse CHD events (CHD-related death and nonfatal myocardial infarction).
All but five trials involved lipid-modifying drugs. After adjustment for changes in low-density lipoprotein (LDL) cholesterol levels related to treatment and drug class, no associations were noted between treatment-medi…