Association Between PPIs and Spontaneous Bacterial Peritonitis

Patients with SBP were more likely to have used PPIs than were patients without SBP.

Lately, proton-pump inhibitor (PPI) use has attracted considerable attention for some possible untoward consequences, including excess risk for several conditions (pneumonia, Clostridium difficile-associated disease, and fractures) and lowered efficacy of concurrent clopidogrel. Now, a retrospective case-control study suggests an association with spontaneous bacterial peritonitis (SBP) in hospitalized patients with cirrhosis and ascites.

Seventy patients with SBP were matched by age and Child’s class to 70 patients without SBP. The prevalence of prehospital use of PPIs was much higher in the SBP group than in the control group (69% vs. 31%). Significantly heightened risk with PPI use persisted in multivariate analysis (odds ratio for associa…

Reviewing Author

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose