Sex Differences in ACS Mortality

Age, comorbidities, and disease severity were factors in the higher 30-day mortality among women.

Prior studies of sex-based differences in mortality for patients with acute coronary syndromes (ACS) have yielded conflicting results. To further explore this subject, investigators used a convenience sample of more than 136,000 patients (28% women) who were enrolled in 11 randomized trials of ACS therapies.

Overall, 30-day mortality was significantly higher in women than in men (9.6% vs. 5.3%). However, women tended to be older and to have higher rates of diabetes, hyperlipidemia, hypertension, and heart failure. After adjustment, mortality did not differ significantly between sexes (odds ratio, 1.06). However, when cases were broken out by type of ACS, sex differences were noted. For example, 30-day mortality was significantly higher among…

Reviewing Author

Kirsten E. Fleischmann, MD, MPH

Disclosures

Grant/Research SupportNational Institutes of Health

Leadership Positions in Professional SocietiesAmerican College of Cardiology/American Heart Association

Kirsten E. Fleischmann, MD, MPH

Disclosures

Grant/Research SupportNational Institutes of Health

Leadership Positions in Professional SocietiesAmerican College of Cardiology/American Heart Association