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Prolonging life expectancy among antiretroviral-naive HIV-positive patients depends heavily on use of antiviral therapy to maintain suppression of viral replication. In an observational cohort study from Europe, researchers assessed the rate of virologic suppression failure among nearly 46,000 antiretroviral-naive patients who started a triple-drug regimen. Patients were followed for as long as 10 years and were included in the analysis if they had received the drugs for at least 4 months. Medication adherence was not assessed.
At 5 years, 3.4% of patients on a triple-drug regimen developed virologic suppression failure; by 9 years, the rate was 8.6%. The incidence of failure rose during years 1 through 3 then plateaued at approximately 1% a…