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The May 10, 2010, issue of Archives of Internal Medicine included four articles about proton-pump inhibitors (PPIs). Investigators evaluated use versus nonuse and higher versus lower doses for various outcomes.
Researchers conducted a meta-analysis of seven randomized trials for bleeding peptic ulcers after endoscopic treatment in which high-dose PPIs (80-mg bolus, followed by 8 mg/hour continuous infusion for 72 hours) were compared with lower-dose PPIs. No 30-day benefit for high doses was found on rate of rebleeding, need for surgical intervention, or mortality.
Investigators from the Women's Health Initiative followed more than 130,000 women without histories of hip fractures for a mean 7.8 years. In multivariate analysis, risk for hip fr…