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In the syndrome of chronic prostatitis/chronic pelvic pain, absence of infection or other obvious etiologies suggests a neuropathic pain mechanism. To test this hypothesis, a multisite federally funded trial was conducted involving 324 men (mean age, 47; 79% white) who had experienced chronic pelvic pain attributed to prostatitis for a mean of 9 years. Participants were randomized to pregabalin (Lyrica; 150 µg daily, increasing to 600 µg daily during 4 weeks) or placebo.
The primary outcome, a clinically important improvement in a validated symptom index at 6 weeks, was achieved by 47% of treated men and 36% of placebo recipients (P=0.07). Several secondary outcomes that included urinary symptoms and overall pain were significantly better in…