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End-stage renal disease is associated with excess cardiovascular mortality. In this prospective population-based Icelandic study that involved nearly 17,000 adults (age range, 33–81) without vascular disease, investigators determined the associations between stage of chronic kidney disease (CKD) and coronary heart disease outcomes (nonfatal myocardial infarction, coronary death, and coronary revascularization), stroke, and nonvascular mortality.
At study entry, 1210 participants (7%) had CKD. During a median follow-up of 24 years, and after adjustment for multiple confounders, participants with CKD had 45% higher overall risk for adverse coronary outcomes than did patients without CKD. Depending on glomerular filtration rate and proteinuria …