Low Glomerular Filtration Rate Is Associated with Future Stroke

Chronic kidney disease (CKD) is associated with elevated risks for coronary heart disease, cardiovascular mortality, and all-cause mortality. The association between low glomerular filtration rate (GFR) and stroke, however, is less clear. In this meta-analysis, investigators explored the association between baseline GFR and future stroke.

Twenty-one articles, derived from 33 prospective studies that involved 285,000 participants, were included in the meta-analysis. In all included studies, investigators adjusted for potential confounding variables. Overall, 7863 stroke events occurred (follow-up range, 3.2–15 years). Risk for stroke was 43% higher among participants with GFRs <60 mL/minute/1.73 m² than among those with normal GFRs. Risk for …