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Moderate alcohol consumption is associated with lower risk for coronary heart disease (CHD). In this systematic review of alcohol intervention studies, investigators assessed the effects of alcohol consumption on biological markers associated with CHD risk in patients who did not have preexisting cardiovascular disease. Overall, 44 studies had data that allowed pooled analyses. In these studies, volunteers ingested specific daily doses of alcohol (studies that allowed patients to drink “usual alcohol” in addition to study alcohol were excluded); blood biomarker levels were measured during periods of alcohol use and of no alcohol use.
A significant dose-response relation was observed between alcohol consumption and HDL cholesterol levels: Ave…