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How does clinical presentation of venous thromboembolism (VTE) and duration of anticoagulation affect risk for recurrent VTE after anticoagulation is stopped? In this pooled analysis of data from seven randomized trials that involved 2925 participants, investigators addressed this question.
Twenty percent of the patients had isolated distal deep venous thrombosis (DVT), 52% had proximal DVT, and 29% had pulmonary embolism (PE). VTE was provoked by a temporary risk factor (e.g., immobilization) in 40%. During mean follow-up of 1.4 years, 312 episodes of recurrent VTE occurred. Risk for recurrent VTE in patients with isolated distal DVT was about half that of patients with proximal DVT or PE. Risk for recurrent VTE was significantly lower afte…