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Based mainly on data derived outside the U.S., an expert panel recently recommended screening for celiac disease in patients with diarrhea-predominant or mixed irritable bowel syndrome (IBS; Am J Gastroenterol 2009; 104 (Suppl 1):S1). Now, researchers have performed a prospective multicenter study to determine the prevalence of celiac disease among 492 U.S. patients with non-constipation–predominant IBS; patients were compared with 458 healthy controls who underwent screening colonoscopy. Each patient and control was tested for four celiac antibodies; those with one or more positive results underwent small bowel biopsy.
The prevalence of at least one abnormal celiac antibody test was not significantly higher in IBS patients than in controls …