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The most common indication for revision hip or knee arthroplasty is implant loosening caused by resorption of bone that supports the implant. In this population-based retrospective cohort study, investigators assessed whether use of bisphosphonates, which have antiresorptive properties, can lengthen implant survival.
Using the U.K.'s General Practice Research Database, researchers identified 42,000 patients who underwent primary total knee or hip arthroplasty from 1986 through 2006. At 5 years, bisphosphonate users (essentially defined as those who took bisphosphonates for at least 6 months) had a significantly lower revision rate than nonusers (0.93% vs. 1.96%). In analyses adjusted for confounding factors, bisphosphonate use was associated…