The Incremental Relation Between Fasting Glucose and Glycosylated Hemoglobin

The relation is affected, in part, by the degree of fasting hyperglycemia and use of oral antidiabetes drugs.

Sometimes glycosylated hemoglobin (HbA_1c) test results don't seem consistent with patients' reported blood glucose levels. In this study, researchers sought to determine whether ethnicity, geographic region, or oral antidiabetes drug use affects the relation between HbA_1c and fasting plasma glucose (FPG) levels. The study involved 12,500 patients worldwide with type 2 diabetes, impaired glucose tolerance, or impaired fasting glucose; none were using insulin.

Results were as follows:

At FPG levels between 100 and 162 mg/dL, an FPG increment of 18 mg/dL was associated with a mean HbA_1c increment of 0.43% in patients who weren't taking oral antidiabetes drugs, and 0.26% in patients who were taking oral antidiabetes drugs
At FPG levels >162 mg/dL,…

Reviewing Author

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose

The Incremental Relation Between Fasting Glucose and Glycosylated Hemoglobin

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Reviewing Author