Kidney Stones Are Associated with Excess Risk for CKD

Chronic kidney disease was more common in people with multiple kidney stone episodes.

Limited evidence suggests that kidney stones are associated with developing chronic kidney disease (CKD). Investigators evaluated this relation in a cohort study of 3 million Canadian adults without end-stage renal disease (ESRD) at baseline.

During a median follow-up of 11 years, 0.8% of patients developed at least one kidney stone, 0.2% developed ESRD, and 4% developed stage 3b-5 CKD (glomerular filtration rate [GFR] <45 mL/minute/1.73 m²). Having one or more kidney stone episodes was associated with significantly higher risks for ESRD (adjusted hazard ratio, 2.2) and new stage 3b-5 chronic kidney disease (AHR, 1.7) compared with having no stone episodes. Doubling of serum creatinine levels was also more common among people with kidney sto…

Reviewing Author

Paul S. Mueller, MD, MPH, FACP

Disclosures

Nothing to disclose

Paul S. Mueller, MD, MPH, FACP

Disclosures

Nothing to disclose