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Echocardiographic assessment of ejection fraction (EF) is used commonly to screen for cardiac toxicity in chemotherapy patients, but what is the best technique for doing so? Researchers studied 56 clinically stable patients who underwent echocardiography (echo) before and during chemotherapy and whose global longitudinal strain (an indicator of systolic function, measured through special echocardiographic techniques) remained stable over time, suggesting continued normal systolic function and lack of chemotherapy-induced cardiotoxicity.
Changes in measured left ventricular volumes and EF during 1 year were assessed by two-dimensional (2-D) and three-dimensional (3-D) echo, both with and without echo contrast. Temporal changes were attributed…