Loading...
Swedish investigators have reported that 60-year-old men with blood prostate-specific antigen (PSA) levels ≤1 µg/L have 0.2% risk for prostate cancer within 25 years (JW Gen Med Oct 7 2010). In this study, the same investigators determined the associations between PSA levels at various ages and subsequent risk for metastatic prostate cancer and prostate cancer–related death.
From 1974 to 1984, 21,000 men (age, ≤52) provided baseline blood samples; 4900 provided additional samples 6 years later. During a median follow-up of 27 years, prostate cancer was diagnosed in 1369 men: Metastatic disease occurred in 241 men, and 163 prostate cancer–related deaths were recorded. Outcomes were as follows:
15-year risk for metastatic prostate cancer was 0.…