Contemporary Outcome of Patients After Surgery for Pancreatic Adenocarcinoma

Microscopically positive resection margins did not predict shorter survival after surgery.

A grossly positive resection margin (R2) after pancreaticoduodenectomy is a poor prognostic factor in patients with pancreatic adenocarcinoma. Some experts have proposed that a microscopically positive margin (R1) could be a biologic predictor of more-aggressive disease as well.

In this large single-institution study from M.D. Anderson Cancer Center, the natural history of 360 consecutive patients who were treated with contemporary multimodal therapy and who underwent pancreaticoduodenectomy with positive margins from 1990 to 2004 was evaluated. All patients met objective computed tomographic criteria for resection. Pathologic analysis of all specimens was undertaken via a standardized system that was defined prospectively. Resection margins…

Reviewing Author

Henry Mark Kuerer, MD, PhD, FACS

Disclosures

Speaker's BureauPhysicians’ Education Resource, LLC

RoyaltiesMcGraw-Hill Professional; UpToDate, Inc.

Editorial BoardsAnnals of Surgical Oncology

Leadership Positions in Professional SocietiesAmerican Society of Breast Surgeons (Chair, Publications Committee)

Henry Mark Kuerer, MD, PhD, FACS

Disclosures

Speaker's BureauPhysicians’ Education Resource, LLC

RoyaltiesMcGraw-Hill Professional; UpToDate, Inc.

Editorial BoardsAnnals of Surgical Oncology

Leadership Positions in Professional SocietiesAmerican Society of Breast Surgeons (Chair, Publications Committee)