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In several randomized trials, researchers have demonstrated improvement in both disease-specific and overall survival among prostate cancer patients with poor risk features when they are treated with androgen-deprivation therapy (ADT) plus external-beam radiotherapy versus radiotherapy alone. However, although adding ADT to radiotherapy provides clear benefit to some patients, recent evidence has suggested an association between use of ADT and substantial cardiac morbidity and mortality.
To evaluate the effects of ADT on men with comorbid illnesses, investigators from several Boston centers randomized 206 men (median age, 72) with prostate cancer (T1b–T2b, N0, M0) and at least one unfavorable prognostic feature (prostate-specific antigen lev…