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Surgical resection is the preferred treatment for patients with early-stage lung cancer or pulmonary metastases. Those who are ineligible for surgery generally are treated with chemotherapy, radiation, or combined modality therapy, if they are considered suitable for such rigorous treatment. Radiofrequency ablation (RFA), a less-invasive potential treatment for nonsurgical patients, has been effective for treating hepatocellular carcinoma (Hepatology 2005; 42:1208) and, in early studies, has shown promise for treating lung nodules and masses (Radiology 2007; 243:268). Pioneered as a minimally invasive technique to remove unresectable solid malignancies, computed tomography–guided, percutaneous RFA entails applying thermal energy to a probe …