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Cancer-related fatigue (CRF) is the most common symptom experienced by cancer patients along the entire trajectory of the disease process. Although few pharmacologic interventions have demonstrated efficacy and safety in ameliorating CRF, some nonpharmacologic techniques show promise. To assess one such technique, two groups of investigators conducted meta-analyses of the benefit of exercise for CRF.
The first group identified 28 randomized controlled trials (RCTs) in which exercise interventions were compared with usual care. Most of the studies (16) involved patients with breast cancer. Interventions varied from unsupervised, home-based programs to supervised, institutional-based programs (duration mode, 12 weeks; range, 3–32 weeks). Fatig…