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Rates of testicular cancer have risen during the past 2 to 3 decades. No consensus has been reached about the underlying causes of this increase, but recent findings have associated it with a concomitant rise in male infertility. To evaluate this potential association further, investigators assessed data from a multicenter cohort of 22,562 men who sought infertility assessment in the U.S.
Of 19,106 evaluable men, 4549 (23.8%) had been diagnosed with male-factor infertility (based on abnormal semen analysis) as defined by World Health Organization criteria. Cancer incidence in this cohort was compared with that in the general population using data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) program.…