Magnetic Resonance Imaging Screening Without Mammography: A New Standard?

In women at high risk for developing breast cancer, the combination of MRI and mammography screening was not substantially better than MRI alone.

Multiple reports demonstrate that magnetic resonance imaging (MRI) is superior to mammographic screening for detecting breast cancer in women at high risk for developing disease (i.e., those who have personal or family histories of breast cancer or BRCA mutations). To compare the abilities of different screening modalities to detect breast cancer in women with ≥20% lifetime risk, investigators conducted a prospective, observational trial of 687 asymptomatic women (median age, 44) who underwent clinical breast examination (CBE), mammography, ultrasound, and MRI annually. All imaging tests were performed within the same 6-week period and were analyzed independently of each other as well as in different combinations. A subgroup of 370 women un…

Reviewing Author

William J. Gradishar, MD

Disclosures

Consultant/Advisory BoardLilly; AstraZeneca; Gilead

Grant/Research SupportBreast Cancer Research Foundation

Editorial BoardsClinical Breast Cancer; Oncology; Annals of Surgery; Breast Cancer Research and Treatment

Leadership Positions in Professional SocietiesNational Comprehensive Cancer Network (Chair, Breast Cancer Panel); American Board of Internal Medicine (Medical Oncology Board)

William J. Gradishar, MD

Disclosures

Consultant/Advisory BoardLilly; AstraZeneca; Gilead

Grant/Research SupportBreast Cancer Research Foundation

Editorial BoardsClinical Breast Cancer; Oncology; Annals of Surgery; Breast Cancer Research and Treatment

Leadership Positions in Professional SocietiesNational Comprehensive Cancer Network (Chair, Breast Cancer Panel); American Board of Internal Medicine (Medical Oncology Board)

Magnetic Resonance Imaging Screening Without Mammography: A New Standard?

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Reviewing Author