Second-Line Panitumumab for Colorectal Cancer

Adding panitumumab to chemotherapy improved progression-free survival and response rate, but not overall survival, in patients with KRAS wild-type CRC.

Advances in first- and second-line chemotherapy have improved the rate of overall survival (OS) in patients with metastatic colorectal cancer (CRC). The anti–epidermal growth factor receptor (EGFR) agents cetuximab and panitumumab are effective for treating patients with advanced CRC who have KRAS wild-type tumors, and treatment with cetuximab plus chemotherapy in first- and second-line therapy has been associated with benefits in progression-free survival (PFS) and antitumor response. Moreover, a recent study demonstrated the effectiveness of panitumumab as part of first-line chemotherapy in patients with KRAS wild-type CRC (JW Oncol Hematol Jan 25 2011).

Now, industry-supported investigators report results of the first study to evaluate pa…

Reviewing Author

David H. Ilson, MD, PhD

Disclosures

Consultant/Advisory BoardAstraZeneca; Merck; Taiho; Astellas; Bristol Myers Squibb; Regeneron; Oncolys; Amgen; Daiichi Sankyo

David H. Ilson, MD, PhD

Disclosures

Consultant/Advisory BoardAstraZeneca; Merck; Taiho; Astellas; Bristol Myers Squibb; Regeneron; Oncolys; Amgen; Daiichi Sankyo