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Patients with diffuse large B-cell lymphoma (DLBCL) who relapse after salvage chemotherapy and autologous stem-cell transplantation (SCT) experience poor outcomes and, typically, short survival. Although allogeneic transplantation is a curative option for these patients, long-term data are limited.
Now, investigators have reviewed records from a European transplantation registry to assess outcomes of adult patients with relapsed DLBCL after prior autologous SCT. A total of 101 such patients underwent allogeneic SCT from 1997 to 2006. Of these, 37 (median age, 43) underwent myeloablative conditioning, and 64 (median age, 54) underwent reduced-intensity conditioning (RIC). Matched sibling donors were used for 72 patients; matched unrelated don…