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A limiting factor in allogeneic hematopoietic cell transplantation is the development of graft-versus-host disease (GVHD). Having the ability to predict response to GVHD-treatment and survival might improve transplant outcomes.
To achieve this goal, investigators collected serum from 112 patients with newly diagnosed acute GVHD and evaluated six biomarkers: tumor necrosis factor receptor-1, interleukin-2-receptor-α, interleukin-8, hepatocyte growth factor, regenerating islet-derived 3-α, and elafin (a skin-specific marker). The relative effects of each biomarker were summarized, and a threshold was set for defining high versus low biomarker panel values.
Results were as follows:
Individuals with high biomarker panel values (32 patients) versus…