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In patients who undergo curative resection for gastric cancer, adjuvant therapy improves survival versus surgery alone. However, treatment preferences vary by region. For example, recommendations are for the use of adjuvant chemotherapy and radiation therapy in the U.S., perioperative chemotherapy in Europe, and adjuvant chemotherapy in Japan.
Now, investigators have conducted a randomized, controlled, open-label, phase III trial to further assess the benefit of adjuvant chemotherapy in patients who underwent D2 gastrectomy for stage II–IIIB gastric cancer at 37 centers in South Korea, China, and Taiwan. A total of 1035 patients (92% were node positive) were assigned to observation or eight 3-week cycles of adjuvant oxaliplatin (130 mg/m2 on…