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Thrombotic microangiopathies (TMAs) are a diverse group of diseases characterized by microvascular thromboses, tissue ischemia, and increases in cellular enzymes such as lactic dehydrogenase (LDH). TMAs often occur in association with inflammation and infection, but how they trigger exacerbations of these disorders is unclear.
Inflammation and infection activate neutrophils, and these cells release complexes of DNA and histones called nucleosomes. To determine whether nucleosomes play a role in TMAs, investigators analyzed nucleosomes, DNA, myeloperoxidase, calpactin, and LDH in the plasma of patients with TMAs of various etiologies, including thrombotic thrombocytopenic purpura (TTP), hemolytic–uremic syndrome, and tumor-associated thrombot…