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Results of small studies have reported benefits from methylphenidate (MPH) for treating core ADHD behaviors in preschool children. Now, results of the Preschool ADHD Treatment Study (PATS), a NIMH-funded, six-center, randomized trial of the efficacy and safety of MPH in preschool children, have been reported in four articles.
Investigators enrolled 303 children (age range, 3–5.5 years) who met DSM-IV criteria for combined-type ADHD in an intensive 10-week behavioral therapy program with their parents. Children whose behaviors had not improved after behavioral therapy and whose parents agreed to a medication trial entered a 5-week, placebo-controlled, double-blind trial in which 165 children were randomized to receive placebo or 1.25 mg, 2.5 …