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Infantile colic is difficult to treat. In a randomized non-blinded trial, Italian investigators assigned 83 breast-fed infants with colic (>3 hours of crying on >3 days/week) to receive the probiotic Lactobacillus reuteri (5 drops once daily 30 minutes after feeding) or the anti-gas medication simethicone (60 mg/day as 15 drops twice a day after feeding) for 28 days. Mothers also were asked to adopt a diet free of cow’s milk.
By day 28 after randomization, mothers of infants in the probiotic group were significantly more likely than mothers of infants in the simethicone group to report a reduction from baseline in average crying time to less than 3 hours per day (95% vs. 7%). In addition, median crying times were significantly shorter in the…