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PFAPA syndrome refers to a constellation of symptoms that include periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA). To broaden our knowledge of this syndrome, physicians in Israel described 54 children (61% boys; 74% Sephardic) who met the diagnostic criteria for early onset of recurring fevers in the absence of upper respiratory infection with aphthous stomatitis, cervical lymphadenitis, or pharyngitis.
Symptoms in this cohort included pharyngitis (96%), abdominal pain (65%), cervical lymphadenopathy (61%), chills (61%), headache (46%), aphthous stomatitis (39%), nausea or vomiting (35%), rhinorrhea (33%), cough (28%), myalgia (22%), diarrhea (13%), and rash (4%). Only 28% of patients manifested all four classic featur…