Loading...
The current recommendation for controlling influenza is to vaccinate all children aged 6 to 59 months with intramuscular (IM) trivalent inactivated influenza vaccine. However, this adds another shot to the immunization schedule, the vaccine’s efficacy is only modest in young children, and the supply is variable. The cold-adapted live attenuated intranasal influenza vaccine might solve these problems, but it has been associated with postvaccination wheezing. In an international, multisite, industry-supported, randomized, double-blind trial, researchers compared intranasal vaccine and IM vaccine in 8352 children aged 6 to 59 months. Previously vaccinated children received one dose, and those who had never been vaccinated received two doses.
Cu…