The CDC no longer recommends fluoroquinolones for treatment of gonococcal infections.
Neisseria gonorrhea historically has been susceptible to a number of antibiotics, including second- and third-generation cephalosporins, fluoroquinolones, azithromycin, and spectinomycin. Azithromycin is not recommended for treatment of gonococcal infections because resistance can develop rapidly, and spectinomycin is not available in the U.S. Fluoroquinolones, particularly ciprofloxacin, often have been used for gonorrhea treatment because they are easily available, are efficacious, and require only one dose. However, in 2000, because of increasing resistance patterns, fluoroquinolones were no longer recommended for treatment of men in Asia, Hawaii, and California, and men who have sex with men.
The most recent data from 26 sites throughout…