Does Family History Predict Thrombophilia Risk in Female Adolescents?

Data on baseline prevalence of all thrombophilia types exist for adults, but less is known about risk for thrombosis in adolescents. Given the increased use of oral contraceptives among adolescents (for a host of conditions ranging from acne to menstrual management) and their association with risk for thrombolytic events, information about family history of thrombophilic events is important. In a retrospective chart review, researchers evaluated the accuracy of family history of early cardiovascular disease (CVD; myocardial infarction or cerebrovascular accident before age 55) and venous thromboembolism (VTE) in predicting a positive thrombophilia screen.

Information about family history of CVD or VTE and laboratory results from the thrombop…